20.500.12556/RUL-141284 Trace elements and APOE polymorphisms in pregnant women and their new-borns We investigated the relationship between lipid binding glycoprotein apolipoprotein E (apoE; gene APOE) polymorphisms (%4 allele carriers versus no carriers = 4+/4%) and trace elements (TEs) (e.g., (methyl)mercury, arsenic, lead, cadmium, selenium, manganese, copper, and zinc) in mothers (N = 223) and their new-borns (N = 213) exposed to potentially toxic metal(loid)s from seafood consumption. The apoE isoform encoded by the %4 allele is believed to have beneficial effects in early life but represents a risk factor for age-associated diseases. Under certain conditions %4 carriers are more susceptible to oxidative stress and metal(loid) toxicity. DNA from Croatian pregnant women (N = 223, third trimester) and their new-borns (N = 176), was genotyped for APOE by TaqMan% SNP assay % rs429358 and rs7412. Seafood intake data and TE levels in maternal urine, milk, hair, peripheral venous blood, mixed cord blood, and new-borns% urine were available from previous studies. We compared TEs between %4+ and %4% carriers using Mann-Whitney U tests and applied multiple linear regression models to analyse the TE%s dependence on the presence of allele %4 (genotypes 3/4,4/4) in combination with other explanatory variables. We identified 17% (n = 37) and 20% (n = 35) %4 allele carriers in mothers and new-borns, respectively. The Mann-Whitney U test showed that mothers with the %4 allele had significantly higher mean levels of (methyl)mercury in peripheral venous blood, cord blood, and hair; arsenic in urine and cord blood; and selenium in peripheral venous blood and plasma. However, taking confounders into account, only the maternal plasma selenium remained statistically significant in the linear regression models (%4 carriers vs non-carriers: 62.6 vs 54.9 ng/mL, p < 0.001). Literature suggestions of possible %4 allele impact on Hg levels were not observed, while superior selenium status observed in healthy pregnant women carrying allele %4 could be linked to the proposed APOE %4 beneficial effects early in life ε4 allele pregnancy selenium mercury trace elements apolipoprotein E polymorphism kemija okolja true false true Angleški jezik Slovenski jezik Članek v reviji 2022-09-28 07:32:00 2022-09-28 07:32:07 2022-09-29 04:03:36 0000-00-00 00:00:00 2020 0 0 Str. 105626-1-105626-13 art. 105626 Vol. 143 2020 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2020-01-01 543 0160-4120 10.1016/j.envint.2020.105626 24060675 1-s2.0-S0160412019337468-main.pdf 1-s2.0-S0160412019337468-main.pdf 1 70F6C9296714080470AF27D884386AF4 abf11defcb8db7ed06481b5de3edb3231e96a0ee9d2f15b11c345e2f3e5ceffa dc038a35-3eef-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162275 https://www.sciencedirect.com/science/article/pii/S0160412019337468?via%3Dihub 0 d048a454-3eef-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162274 Fakulteta za farmacijo Biotehniška fakulteta 0 0 0