Association of myocardial infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 polymorphism in Slovenian subjects with type 2 diabetes mellitus

Tibaut, Miha (avtor), Naji, Franjo (avtor), Petrovič, Danijel (avtor)

Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.

• Jezik: Angleški jezik
• Ključne besede: type 2 diabetes mellitus, myocardial infarction, coronary artery disease, Cyclin Dependent Kinase Inhibitor 2B Antisense RNA 1, CDKN2B-AS1, rs1333049
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 8 str.
• Številčenje: Vol. 13, iss. 3, art. 526
• PID: 20.500.12556/RUL-137533
• UDK: 616.1
• ISSN pri članku: 2073-4425
• DOI: 10.3390/genes13030526
• COBISS.SI-ID: 102534915
• Datum objave v RUL: 21.06.2022

Gradivo je del revije

• Naslov: Genes
• Skrajšan naslov: Genes
• Založnik: Multidisciplinary Digital Publishing Institute (MDPI)
• ISSN: 2073-4425
• COBISS.SI-ID: 523100185

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 16.03.2022

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: sladkorna bolezen tip 2, miokardni infarkt, bolezen koronarnih arterij