Association of myocardial infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 polymorphism in Slovenian subjects with type 2 diabetes mellitus

Tibaut, Miha (author), Naji, Franjo (author), Petrovič, Danijel (author)

Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.

• Language: English
• Keywords: type 2 diabetes mellitus, myocardial infarction, coronary artery disease, Cyclin Dependent Kinase Inhibitor 2B Antisense RNA 1, CDKN2B-AS1, rs1333049
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 8 str.
• Numbering: Vol. 13, iss. 3, art. 526
• PID: 20.500.12556/RUL-137533
• UDC: 616.1
• ISSN on article: 2073-4425
• DOI: 10.3390/genes13030526
• COBISS.SI-ID: 102534915
• Publication date in RUL: 21.06.2022

Record is a part of a journal

• Title: Genes
• Shortened title: Genes
• Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
• ISSN: 2073-4425
• COBISS.SI-ID: 523100185

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 16.03.2022

Secondary language

• Language: Slovenian
• Keywords: sladkorna bolezen tip 2, miokardni infarkt, bolezen koronarnih arterij