Histopathological and immunohistochemical evaluation of canine nerve sheath tumors and proposal for an update classification

Tekavec, Kristina (avtor), Švara, Tanja (avtor), Knific, Tanja (avtor), Gombač, Mitja (avtor), Cantile, Carlo (avtor)

Nerve sheath tumors are a group of tumors originating from Schwann cells, fibroblasts, and perineurial cells. In veterinary pathology, the terminology for nerve sheath tumors remains inconsistent, and many pathologists follow the human classification of such tumors in practice. Immunohistochemistry plays an important role in the diagnosis of nerve sheath tumors, but specific immunohistochemical and molecular biomarkers are lacking. In our study, we histopathologically reevaluated 79 canine nerve sheath tumors and assessed their reactivity for the immunohistochemical markers Sox10, claudin-1, GFAP, CNPase, and Ki-67. Based on the results, we classified the tumors according to the most recent human classification. Twelve cases were diagnosed as benign nerve sheath tumors, including six neurofibromas, three nerve sheath myxomas, two hybrid nerve sheath tumors (perineurioma/neurofibroma and perineurioma/schwannoma), and one schwannoma. Sixty-seven tumors were malignant nerve sheath tumors, including fifty-six conventional, four perineural, one epithelioid malignant nerve sheath tumor, and six malignant nerve sheath tumors with divergent differentiation. We believe that with the application of the proposed panel, an updated classification of canine nerve sheath tumors could largely follow the recent humanWHOclassification of tumors of the cranial and paraspinal nerves, but prospective studies would be needed to assess its prognostic value.

• Jezik: Angleški jezik
• Ključne besede: dog, nerve sheath tumor, histopathology, immunohistochemistry, Sox10, claudin-1, GFAP, CNPase, Ki-67
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 27 str.
• Številčenje: Vol. 9, no. 5, art. 204
• PID: 20.500.12556/RUL-137092
• UDK: 636.09:616-006
• ISSN pri članku: 2306-7381
• DOI: 10.3390/vetsci9050204
• COBISS.SI-ID: 106797315
• Datum objave v RUL: 01.06.2022

Gradivo je del revije

• Naslov: Veterinary sciences
• Skrajšan naslov: Vet. sci.
• Založnik: MDPI
• ISSN: 2306-7381
• COBISS.SI-ID: 523429657

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.06.2022

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0092
• Naslov: Zdravje živali, okolje in varna hrana