Histopathological and immunohistochemical evaluation of canine nerve sheath tumors and proposal for an update classification

Tekavec, Kristina (author), Švara, Tanja (author), Knific, Tanja (author), Gombač, Mitja (author), Cantile, Carlo (author)

Nerve sheath tumors are a group of tumors originating from Schwann cells, fibroblasts, and perineurial cells. In veterinary pathology, the terminology for nerve sheath tumors remains inconsistent, and many pathologists follow the human classification of such tumors in practice. Immunohistochemistry plays an important role in the diagnosis of nerve sheath tumors, but specific immunohistochemical and molecular biomarkers are lacking. In our study, we histopathologically reevaluated 79 canine nerve sheath tumors and assessed their reactivity for the immunohistochemical markers Sox10, claudin-1, GFAP, CNPase, and Ki-67. Based on the results, we classified the tumors according to the most recent human classification. Twelve cases were diagnosed as benign nerve sheath tumors, including six neurofibromas, three nerve sheath myxomas, two hybrid nerve sheath tumors (perineurioma/neurofibroma and perineurioma/schwannoma), and one schwannoma. Sixty-seven tumors were malignant nerve sheath tumors, including fifty-six conventional, four perineural, one epithelioid malignant nerve sheath tumor, and six malignant nerve sheath tumors with divergent differentiation. We believe that with the application of the proposed panel, an updated classification of canine nerve sheath tumors could largely follow the recent humanWHOclassification of tumors of the cranial and paraspinal nerves, but prospective studies would be needed to assess its prognostic value.

• Language: English
• Keywords: dog, nerve sheath tumor, histopathology, immunohistochemistry, Sox10, claudin-1, GFAP, CNPase, Ki-67
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 27 str.
• Numbering: Vol. 9, no. 5, art. 204
• PID: 20.500.12556/RUL-137092
• UDC: 636.09:616-006
• ISSN on article: 2306-7381
• DOI: 10.3390/vetsci9050204
• COBISS.SI-ID: 106797315
• Publication date in RUL: 01.06.2022

Record is a part of a journal

• Title: Veterinary sciences
• Shortened title: Vet. sci.
• Publisher: MDPI
• ISSN: 2306-7381
• COBISS.SI-ID: 523429657

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.06.2022

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0092
• Name: Zdravje živali, okolje in varna hrana