izpis_h1_title_alt

Ibogaine has sex-specific plasma bioavailability, histopathological and redox/antioxidant effects in rat liver and kidneys : a study on females
ID Tatalović, Nikola (Avtor), ID Vidonja-Uzelac, Teodora (Avtor), ID Mijović, Milica (Avtor), ID Koželj, Gordana (Avtor), ID Nikolić-Kokić, Aleksandra (Avtor), ID Oreščanin-Dušić, Zorana (Avtor), ID Bresjanac, Mara (Avtor), ID Blagojević, Duško (Avtor)

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Izvleček
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.

Jezik:Angleški jezik
Ključne besede:noribogaine, erythrocytes, liver, kidney, glycogen, redox imbalance, catalase, xanthine oxidase, lipid peroxidation, thiols
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:18 str.
Številčenje:Vol. 12, iss. 1, art. 16
PID:20.500.12556/RUL-136896 Povezava se odpre v novem oknu
UDK:616-092
ISSN pri članku:2075-1729
DOI:10.3390/life12010016 Povezava se odpre v novem oknu
COBISS.SI-ID:96210947 Povezava se odpre v novem oknu
Datum objave v RUL:24.05.2022
Število ogledov:497
Število prenosov:84
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Life
Skrajšan naslov:Life
Založnik:MDPI
ISSN:2075-1729
COBISS.SI-ID:519982617 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.01.2022

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:noribogain, eritrociti, jetra

Projekti

Financer:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:451-03-68/2020-14/200007

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0171
Naslov:Plastičnost živčevja v fizioloških in patofizioloških razmerah

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