Ibogaine has sex-specific plasma bioavailability, histopathological and redox/antioxidant effects in rat liver and kidneys : a study on females

Tatalović, Nikola (author), Vidonja-Uzelac, Teodora (author), Mijović, Milica (author), Koželj, Gordana (author), Nikolić-Kokić, Aleksandra (author), Oreščanin-Dušić, Zorana (author), Bresjanac, Mara (author), Blagojević, Duško (author)

Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.

• Language: English
• Keywords: noribogaine, erythrocytes, liver, kidney, glycogen, redox imbalance, catalase, xanthine oxidase, lipid peroxidation, thiols
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 18 str.
• Numbering: Vol. 12, iss. 1, art. 16
• PID: 20.500.12556/RUL-136896
• UDC: 616-092
• ISSN on article: 2075-1729
• DOI: 10.3390/life12010016
• COBISS.SI-ID: 96210947
• Publication date in RUL: 24.05.2022

Record is a part of a journal

• Title: Life
• Shortened title: Life
• Publisher: MDPI
• ISSN: 2075-1729
• COBISS.SI-ID: 519982617

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.01.2022

Secondary language

• Language: Slovenian
• Keywords: noribogain, eritrociti, jetra

Projects

• Funder: MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
• Project number: 451-03-68/2020-14/200007

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0171
• Name: Plastičnost živčevja v fizioloških in patofizioloških razmerah