izpis_h1_title_alt

Comparison of solution chemical properties and biological activity of ruthenium complexes of selected ß-diketone, 8-hydroxyquinoline and pyrithione ligands
ID Pivarcsik, Tamás (Avtor), ID Tóth, Gábor (Avtor), ID Szemerédi, Nikoletta (Avtor), ID Bogdanov, Anita (Avtor), ID Spengler, Gabriella (Avtor), ID Kljun, Jakob (Avtor), ID Kladnik, Jerneja (Avtor), ID Turel, Iztok (Avtor), ID Enyedy, Éva A. (Avtor)

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Izvleček
In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl$^−$ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,Spyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.

Jezik:Angleški jezik
Ključne besede:MTT assay, UV-vis, solution stability, MRSA, albumin binding, ligand effect
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2021
Št. strani:24 str.
Številčenje:Vol. 14, iss. 6, art. 518
PID:20.500.12556/RUL-135430 Povezava se odpre v novem oknu
UDK:546.96:547.8
ISSN pri članku:1424-8247
DOI:10.3390/ph14060518 Povezava se odpre v novem oknu
COBISS.SI-ID:65179139 Povezava se odpre v novem oknu
Datum objave v RUL:14.03.2022
Število ogledov:1053
Število prenosov:100
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Pharmaceuticals
Skrajšan naslov:Pharmaceuticals
Založnik:MDPI
ISSN:1424-8247
COBISS.SI-ID:517582617 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.06.2021

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:rutenij, organorutenijevi kompleksi, ligandi, kemijske lastnosti, biološka aktivnost

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:National Research, Development and Innovation Office-NKFIA
Številka projekta:FK124240

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Hungary, Ministry of Human Capacities
Številka projekta:TKP-2020

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:Junior Researcher

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0175
Naslov:Napredna anorganska kemija

Financer:Drugi - Drug financer ali več financerjev
Program financ.:COST
Številka projekta:CA17104
Akronim:STRATAGEM

Financer:Drugi - Drug financer ali več financerjev
Program financ.:COST
Številka projekta:CA18202
Akronim:NECTAR

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