20.500.12556/RUL-135430 Comparison of solution chemical properties and biological activity of ruthenium complexes of selected ß-diketone, 8-hydroxyquinoline and pyrithione ligands In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl$^−$ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,Spyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity. MTT assay UV-vis solution stability MRSA albumin binding ligand effect rutenij organorutenijevi kompleksi ligandi kemijske lastnosti biološka aktivnost true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-14 12:20:12 2022-03-14 12:20:13 2022-09-14 04:13:16 0000-00-00 00:00:00 2021 0 0 24 str. iss. 6, art. 518 Vol. 14 Jun. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.96:547.8 1424-8247 10.3390/ph14060518 65179139 RAZ_Pivarcsik_Tamas_2021.pdf RAZ_Pivarcsik_Tamas_2021.pdf 1 263BD5CB67BBEF3D1D561097D2E3BC90 91418840804795c97410cadb0d1689bff7c67566f5f06a6fef0b46584e2ada3f 07b563d6-a389-11ec-8556-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154500 https://www.mdpi.com/1424-8247/14/6/518 0 b7ab10ab-a388-11ec-8556-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154499 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0