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Structural characterization, antimicrobial activity and BSA/DNA binding affinity of new silver(I) complexes with thianthrene and 1,8-naphthyridine
ID
Ašanin, Darko P.
(
Avtor
),
ID
Skaro-Bogojevic, Sanja
(
Avtor
),
ID
Perdih, Franc
(
Avtor
),
ID
Andrejević, Tina P.
(
Avtor
),
ID
Milivojević, Dušan
(
Avtor
),
ID
Aleksić, Ivana
(
Avtor
),
ID
Nikodinović-Runić, Jasmina
(
Avtor
),
ID
Glišić, Biljana Đ.
(
Avtor
),
ID
Turel, Iztok
(
Avtor
),
ID
Djuran, Miloš I.
(
Avtor
)
PDF - Predstavitvena datoteka,
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(2,48 MB)
MD5: 5C62AD59DD25D617047319269A69CAA4
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1420-3049/26/7/1871
Galerija slik
Izvleček
Three new silver(I) complexes [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ (Ag1), [Ag(CF$_3$SO$_3$)(1,8-naph)]$_n$ (Ag2) and [Ag$_2$(1,8-naph)$_2$(H$_2$O)$_{1.2}$](PF$_6$)$_2$ (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56–7.81 µg/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1–3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.
Jezik:
Angleški jezik
Ključne besede:
silver(I) complexes
,
thianthrene
,
1
,
8-naphthyridine
,
antimicrobial activity
,
Caenorhabditis elegans
,
DNA/BSA interaction
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
20 str.
Številčenje:
Vol. 26, iss. 7, art. 1871
PID:
20.500.12556/RUL-135345
UDK:
546.571
ISSN pri članku:
1420-3049
DOI:
10.3390/molecules26071871
COBISS.SI-ID:
57510915
Datum objave v RUL:
08.03.2022
Število ogledov:
818
Število prenosov:
112
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Molecules
Skrajšan naslov:
Molecules
Založnik:
MDPI
ISSN:
1420-3049
COBISS.SI-ID:
18462981
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.04.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
srebro(I)
,
srebrovi kompleksi
Projekti
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-68/2021-14/200042
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-68/2021-14/200122
Financer:
MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:
451-03-68/2021-14/200378
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0175
Naslov:
Napredna anorganska kemija
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Serbian Academy of Sciences and Arts
Številka projekta:
01-2019-F65
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Serbian Academy of Sciences and Arts
Številka projekta:
F128
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