Structural characterization, antimicrobial activity and BSA/DNA binding affinity of new silver(I) complexes with thianthrene and 1,8-naphthyridine

Ašanin, Darko P. (author), Skaro-Bogojevic, Sanja (author), Perdih, Franc (author), Andrejević, Tina P. (author), Milivojević, Dušan (author), Aleksić, Ivana (author), Nikodinović-Runić, Jasmina (author), Glišić, Biljana Đ. (author), Turel, Iztok (author), Djuran, Miloš I. (author)

Three new silver(I) complexes [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ (Ag1), [Ag(CF$_3$SO$_3$)(1,8-naph)]$_n$ (Ag2) and [Ag$_2$(1,8-naph)$_2$(H$_2$O)$_{1.2}$](PF$_6$)$_2$ (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56–7.81 µg/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1–3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.

• Language: English
• Keywords: silver(I) complexes, thianthrene, 1, 8-naphthyridine, antimicrobial activity, Caenorhabditis elegans, DNA/BSA interaction
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 20 str.
• Numbering: Vol. 26, iss. 7, art. 1871
• PID: 20.500.12556/RUL-135345
• UDC: 546.571
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules26071871
• COBISS.SI-ID: 57510915
• Publication date in RUL: 08.03.2022

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.04.2021

Secondary language

• Language: Slovenian
• Keywords: srebro(I), srebrovi kompleksi