Glucagon-like peptide 1 and taste perception : from molecular mechanisms to potential clinical implications

Jensterle Sever, Mojca (avtor), Rizzo, Manfredi (avtor), Janež, Andrej (avtor)

Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.

• Jezik: Angleški jezik
• Ključne besede: glucagon-like peptide 1 (GLP-1), taste, tongue, obesity, sweet
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 13 str.
• Številčenje: Vol. 22, iss. 2, art. 902
• PID: 20.500.12556/RUL-134959
• UDK: 616.379
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms22020902
• COBISS.SI-ID: 47378691
• Datum objave v RUL: 14.02.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 18.01.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: glukagonu podoben peptid 1 (GLP-1), okus, jezik, debelost, sladko