Glucagon-like peptide 1 and taste perception : from molecular mechanisms to potential clinical implications

Jensterle Sever, Mojca (author), Rizzo, Manfredi (author), Janež, Andrej (author)

Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.

• Language: English
• Keywords: glucagon-like peptide 1 (GLP-1), taste, tongue, obesity, sweet
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 13 str.
• Numbering: Vol. 22, iss. 2, art. 902
• PID: 20.500.12556/RUL-134959
• UDC: 616.379
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms22020902
• COBISS.SI-ID: 47378691
• Publication date in RUL: 14.02.2022

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 18.01.2021

Secondary language

• Language: Slovenian
• Keywords: glukagonu podoben peptid 1 (GLP-1), okus, jezik, debelost, sladko