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Insights into cell surface expression, supramolecular organization, and functions of aquaporin 4 isoforms in astrocytes
ID Jorgačevski, Jernej (Avtor), ID Zorec, Robert (Avtor), ID Potokar, Maja (Avtor)

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Izvleček
Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS). Its expression is confined to non-neuronal glial cells, predominantly to astrocytes that represent a heterogeneous glial cell type in the CNS. The membrane of astrocyte processes, which align brain capillaries and pia, is particularly rich in AQP4. Several isoforms of AQP4 have been described; however, only some (AQP4a (M1), AQP4 c (M23), AQP4e, and AQP4ex) have been identified in the plasma membrane assemblies of astrocytes termed orthogonal arrays of particles (OAPs). Intracellular splicing isoforms (AQP4b, AQP4d, AQP4f, AQP4-∆4) have been documented, and most of them are postulated to have a role in the cell surface distribution of the plasma membrane isoforms and in the formation of OAPs in murine and human astrocytes. Although OAPs have been proposed to play various roles in the functioning of astrocytes and CNS tissue as a whole, many of these still need to be described. OAPs are studied primarily from the perspective of understanding water permeability regulation through the plasma membrane and of their involvement in cell adhesion and in the dynamics of astrocytic processes. This review describes the cellular distribution of various AQP4 isoforms and their implications in OAP assembly, which is regulated by several intracellular and extracellular proteins.

Jezik:Angleški jezik
Ključne besede:aquaporin 4 (AQP4), astrocyte, brain edema, glia, orthogonal arrays of particles (OAP), cell migration, extracellular matrix, hormones
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:19 str.
Številčenje:Vol. 9, iss. 12, art. 2622
UDK:616-092
ISSN pri članku:2073-4409
DOI:10.3390/cells9122622 Povezava se odpre v novem oknu
COBISS.SI-ID:41327875 Povezava se odpre v novem oknu
Datum objave v RUL:02.02.2022
Število ogledov:114
Število prenosov:52
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Cells
Skrajšan naslov:Cells
Založnik:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:07.12.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:akvaporin 4 (AQP4), astrocit, edem možganov

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0310
Naslov:Celična fiziologija

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:J3-9266
Naslov:Uravnavanje fuzijske pore in motnje skladiščenja v lizosomih

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