20.500.12556/RUL-134806 Insights into cell surface expression, supramolecular organization, and functions of aquaporin 4 isoforms in astrocytes Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS). Its expression is confined to non-neuronal glial cells, predominantly to astrocytes that represent a heterogeneous glial cell type in the CNS. The membrane of astrocyte processes, which align brain capillaries and pia, is particularly rich in AQP4. Several isoforms of AQP4 have been described; however, only some (AQP4a (M1), AQP4 c (M23), AQP4e, and AQP4ex) have been identified in the plasma membrane assemblies of astrocytes termed orthogonal arrays of particles (OAPs). Intracellular splicing isoforms (AQP4b, AQP4d, AQP4f, AQP4-∆4) have been documented, and most of them are postulated to have a role in the cell surface distribution of the plasma membrane isoforms and in the formation of OAPs in murine and human astrocytes. Although OAPs have been proposed to play various roles in the functioning of astrocytes and CNS tissue as a whole, many of these still need to be described. OAPs are studied primarily from the perspective of understanding water permeability regulation through the plasma membrane and of their involvement in cell adhesion and in the dynamics of astrocytic processes. This review describes the cellular distribution of various AQP4 isoforms and their implications in OAP assembly, which is regulated by several intracellular and extracellular proteins. aquaporin 4 (AQP4) astrocyte brain edema glia orthogonal arrays of particles (OAP) cell migration extracellular matrix hormones akvaporin 4 (AQP4) astrocit edem možganov true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-02 11:50:16 2022-02-02 11:50:21 2022-09-14 04:10:02 0000-00-00 00:00:00 2020 0 0 19 str. iss. 12, art. 2622 Vol. 9 Dec. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 2073-4409 10.3390/cells9122622 41327875 RAZ_Jorgacevski_Jernej_2020.pdf RAZ_Jorgacevski_Jernej_2020.pdf 1 B8A01BAE33FCFD1B227D576E6A6935BC 420c3144adc72028c35be31e5beacaae6027e5e5b939f8e3de38c4e51f1af37f ec288e28-8415-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153463 https://www.mdpi.com/2073-4409/9/12/2622 1 b359acad-8415-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153462 Medicinska fakulteta 0 0 0