Magnetic resonance methods as a prognostic tool for the biorelevant behavior of xanthan tablets

Mikac, Urška (avtor), Kristl, Julijana (avtor)

Hydrophilic matrix tablets with controlled drug release have been used extensively as one of the most successful oral drug delivery systems for optimizing therapeutic efficacy. In this work, magnetic resonance imaging (MRI) is used to study the influence of various pHs and mechanical stresses caused by medium flow (at rest, 80, or 150 mL/min) on swelling and on pentoxifylline release from xanthan (Xan) tablets. Moreover, a bimodal MRI system with simultaneous release testing enables measurements of hydrogel thickness and drug release, both under the same experimental conditions and at the same time. The results show that in water, the hydrogel structure is weaker and less resistant to erosion than the Xan structure in the acid medium. Different hydrogel structures affect drug release with erosion controlled release in water and diffusion controlled release in the acid medium. Mechanical stress simulating gastrointestinal contraction has no effect on the hard hydrogel in the acid medium where the release is independent of the tested stress, while it affects the release from the weak hydrogel in water with faster release under high stress. Our findings suggest that simultaneous MR imaging and drug release from matrix tablets together provide a valuable prognostic tool for prolonged drug delivery design.

• Jezik: Angleški jezik
• Ključne besede: hydrophilic matrix tablets, magnetic resonance, hydrogel, drug release, biorelevant dynamic conditions
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 12 str.
• Številčenje: Vol. 25, iss. 24, art. 5871
• PID: 20.500.12556/RUL-134803
• UDK: 537.635:615.015.14
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules25245871
• COBISS.SI-ID: 42432771
• Datum objave v RUL: 02.02.2022

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 11.12.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: hidrofilne matrične tablete, sproščanje učinkovin, hidrogeli, dostavni sistemi, magnetna resonanca