20.500.12556/RUL-134803 Magnetic resonance methods as a prognostic tool for the biorelevant behavior of xanthan tablets Hydrophilic matrix tablets with controlled drug release have been used extensively as one of the most successful oral drug delivery systems for optimizing therapeutic efficacy. In this work, magnetic resonance imaging (MRI) is used to study the influence of various pHs and mechanical stresses caused by medium flow (at rest, 80, or 150 mL/min) on swelling and on pentoxifylline release from xanthan (Xan) tablets. Moreover, a bimodal MRI system with simultaneous release testing enables measurements of hydrogel thickness and drug release, both under the same experimental conditions and at the same time. The results show that in water, the hydrogel structure is weaker and less resistant to erosion than the Xan structure in the acid medium. Different hydrogel structures affect drug release with erosion controlled release in water and diffusion controlled release in the acid medium. Mechanical stress simulating gastrointestinal contraction has no effect on the hard hydrogel in the acid medium where the release is independent of the tested stress, while it affects the release from the weak hydrogel in water with faster release under high stress. Our findings suggest that simultaneous MR imaging and drug release from matrix tablets together provide a valuable prognostic tool for prolonged drug delivery design. hydrophilic matrix tablets magnetic resonance hydrogel drug release biorelevant dynamic conditions hidrofilne matrične tablete sproščanje učinkovin hidrogeli dostavni sistemi magnetna resonanca true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-02 11:14:36 2022-02-02 11:14:40 2022-09-14 04:10:01 0000-00-00 00:00:00 2020 0 0 12 str. iss. 24, art. 5871 Vol. 25 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 537.635:615.015.14 1420-3049 10.3390/molecules25245871 42432771 RAZ_Mikac_Urska_2020.pdf RAZ_Mikac_Urska_2020.pdf 1 5F0FB4EB744351C0C58B9A6ED2DDFA2C ea2938fad26bf17a8e8107b919258b642bc7a881f583ff4bff2f6192dce0460f e5f67385-8410-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153458 https://www.mdpi.com/1420-3049/25/24/5871 1 b753d542-8410-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153457 Fakulteta za farmacijo 0 0 0