izpis_h1_title_alt

High-sensitivity C-reactive protein and carotid intima media thickness as markers of subclinical inflammation and atherosclerosis in pediatric patients with hypercholesterolemia
ID Blinc, Lana (Avtor), ID Mlinarič, Matej (Avtor), ID Battelino, Tadej (Avtor), ID Grošelj, Urh (Avtor)

.pdfPDF - Predstavitvena datoteka, prenos (249,60 KB)
MD5: 733F9C4BCB775D00BF4F1E38B8322ACD
URLURL - Izvorni URL, za dostop obiščite https://www.mdpi.com/1420-3049/25/21/5118 Povezava se odpre v novem oknu

Izvleček
Hypercholesterolemia is a major cause of atherosclerosis development and premature cardiovascular disease (CVD). It leads to inflammation, which further accelerates atherosclerosis progression. Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated serum LDL-c from birth, due to a disease-causing variant in one of the causative genes (LDLR, APOB, PCSK9). In polygenic hypercholesterolemia (PH), the disease-causing genetic variant is absent; it is likely the cumulative result of multiple single nucleotide polymorphisms in LDL metabolism-related genes and other factors, such as lifestyle and environment. In high risk groups, such as patients with FH, an effective primary prevention of CVD must begin in childhood. High-sensitivity C-reactive protein (hsCRP) and carotid intima media thickness (cIMT) are two potential minimally invasive correlates of inflammation and subclinical atherosclerosis progression. hsCRP and cIMT have been shown to be significantly increased in patients with FH and PH relative to healthy controls, with some studies yielding conflicting results. In this review, we aim to summarize current knowledge and recent findings regarding the applicability of hsCRP and cIMT as markers of low-grade inflammation and subclinical atherosclerosis, focusing especially on children and adolescents with hypercholesterolemia.

Jezik:Angleški jezik
Ključne besede:familial hypercholesterolemia, polygenic hypercholesterolemia, inflammation, atherosclerosis, carotid intima media thickness, cIMT, C-reactive protein, hsCRP
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:14 str.
Številčenje:Vol. 25, iss. 21, art. 5118
PID:20.500.12556/RUL-134722 Povezava se odpre v novem oknu
UDK:616.053.2
ISSN pri članku:1420-3049
DOI:10.3390/molecules25215118 Povezava se odpre v novem oknu
COBISS.SI-ID:37628419 Povezava se odpre v novem oknu
Datum objave v RUL:27.01.2022
Število ogledov:217
Število prenosov:54
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
:
Kopiraj citat
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:04.11.2020

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-2356
Naslov:Izražanje in funkcionalna analiza nekodirajočih RNA pri parkinsonovi bolezni

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0343
Naslov:Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Nazaj