20.500.12556/RUL-134722 High-sensitivity C-reactive protein and carotid intima media thickness as markers of subclinical inflammation and atherosclerosis in pediatric patients with hypercholesterolemia Hypercholesterolemia is a major cause of atherosclerosis development and premature cardiovascular disease (CVD). It leads to inflammation, which further accelerates atherosclerosis progression. Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated serum LDL-c from birth, due to a disease-causing variant in one of the causative genes (LDLR, APOB, PCSK9). In polygenic hypercholesterolemia (PH), the disease-causing genetic variant is absent; it is likely the cumulative result of multiple single nucleotide polymorphisms in LDL metabolism-related genes and other factors, such as lifestyle and environment. In high risk groups, such as patients with FH, an effective primary prevention of CVD must begin in childhood. High-sensitivity C-reactive protein (hsCRP) and carotid intima media thickness (cIMT) are two potential minimally invasive correlates of inflammation and subclinical atherosclerosis progression. hsCRP and cIMT have been shown to be significantly increased in patients with FH and PH relative to healthy controls, with some studies yielding conflicting results. In this review, we aim to summarize current knowledge and recent findings regarding the applicability of hsCRP and cIMT as markers of low-grade inflammation and subclinical atherosclerosis, focusing especially on children and adolescents with hypercholesterolemia. familial hypercholesterolemia polygenic hypercholesterolemia inflammation atherosclerosis carotid intima media thickness cIMT C-reactive protein hsCRP true false true Angleški jezik Ni določen Članek v reviji 2022-01-27 14:43:46 2022-01-27 14:43:46 2022-09-14 04:09:33 0000-00-00 00:00:00 2020 0 0 14 str. iss. 21, art. 5118 Vol. 25 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.053.2 1420-3049 10.3390/molecules25215118 37628419 RAZ_Blinc_Lana_2020.pdf RAZ_Blinc_Lana_2020.pdf 1 733F9C4BCB775D00BF4F1E38B8322ACD eea61ce94b76b5f68d411e5cb3c24df58549cdb61c1eb616cff5d9ce797173e3 2e888f08-7f77-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153325 https://www.mdpi.com/1420-3049/25/21/5118 1 f21ba8fb-7f76-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153324 Medicinska fakulteta 0 0 0