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Determining the molecular background of endometrial receptivity in adenomyosis
ID
Prašnikar, Erika
(
Avtor
),
ID
Kunej, Tanja
(
Avtor
),
ID
Repnik, Katja
(
Avtor
),
ID
Potočnik, Uroš
(
Avtor
),
ID
Knez, Jure
(
Avtor
),
ID
Kovačič, Borut
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(5,01 MB)
MD5: FE6CA367C8E02F2D14EE771228E00B16
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2218-273X/10/9/1311
Galerija slik
Izvleček
Background: Adenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns. Therefore, the candidate genes identified in endometriosis could serve as a source to study endometrial function in adenomyosis. Methods: Transcripts/proteins associated with endometrial receptivity in women with adenomyosis or endometriosis and healthy women were obtained from publications and their nomenclature was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Retrieved genes were analysed for enriched pathways using Cytoscape/Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Reactome tools to prioritise candidates for endometrial receptivity. These were used for validation on women with (n = 9) and without (n = 13) adenomyosis. Results: Functional enrichment analysis of 173, 42 and 151 genes associated with endometriosis, adenomyosis and healthy women, respectively, revealed signalling by interleukins and interleukin-4 and interleukin-13 signalling pathways, from which annotated LIF, JUNB, IL6, FOS, IL10 and SOCS3 were prioritised. Selected genes showed downregulated expression levels in adenomyosis compared to the control group, but without statistical significance. Conclusion: This is the first integrative study providing putative candidate genes and pathways characterising endometrial receptivity in women with adenomyosis in comparison to healthy women and women with endometriosis.
Jezik:
Angleški jezik
Ključne besede:
candidate genes
,
endometrial receptivity
,
gene set enrichment analysis (GSEA)
,
multi-omics
,
protein-protein interaction network (PPIN)
,
adenomyosis
,
endometriosis
,
gene expression
,
genetic association studies
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
25 str.
Številčenje:
Vol. 10, iss. 9, art. 1311
PID:
20.500.12556/RUL-134656
UDK:
618.14-002
ISSN pri članku:
2218-273X
DOI:
10.3390/biom10091311
COBISS.SI-ID:
28211459
Datum objave v RUL:
24.01.2022
Število ogledov:
1328
Število prenosov:
156
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Biomolecules
Skrajšan naslov:
Biomolecules
Založnik:
MDPI
ISSN:
2218-273X
COBISS.SI-ID:
519952921
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
11.09.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
endometrioza
,
genetske asociacijske študije
,
gensko izražanje
,
adenomioza
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0327
Naslov:
Reprodukcija človeka - laboratorijski in eksperimentalni vidiki
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0220
Naslov:
Primerjalna genomika in genomska biodiverziteta
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