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Natural and synthetic derivatives of hydroxycinnamic acid modulating the pathological transformation of amyloidogenic proteins
ID Muronetz, Vladimir I. (Avtor), ID Barinova, Kseniya (Avtor), ID Kudryavtseva, Sofia (Avtor), ID Medvedeva, Maria (Avtor), ID Melnikova, Aleksandra (Avtor), ID Sevostyanova, Irina (Avtor), ID Semenyuk, Pavel (Avtor), ID Stroylova, Yulia (Avtor), ID Sova, Matej (Avtor)

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Izvleček
This review presents the main properties of hydroxycinnamic acid (HCA) derivatives and their potential application as agents for the prevention and treatment of neurodegenerative diseases. It is partially focused on the successful use of these compounds as inhibitors of amyloidogenic transformation of proteins. Firstly, the prerequisites for the emergence of interest in HCA derivatives, including natural compounds, are described. A separate section is devoted to synthesis and properties of HCA derivatives. Then, the results of molecular modeling of HCA derivatives with prion protein as well as with α-synuclein fibrils are summarized, followed by detailed analysis of the experiments on the effect of natural and synthetic HCA derivatives, as well as structurally similar phenylacetic and benzoic acid derivatives, on the pathological transformation of prion protein and α-synuclein. The ability of HCA derivatives to prevent amyloid transformation of some amyloidogenic proteins, and their presence not only in food products but also as natural metabolites in human blood and tissues, makes them promising for the prevention and treatment of neurodegenerative diseases of amyloid nature.

Jezik:Angleški jezik
Ključne besede:neurodegenerative diseases, curcumin, derivatives of hydroxycinnamic acid, amyloid, α-synuclein, prion protein, amyloid fibrils, prevention of amyloid transformation, Parkinson's disease
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:28 str.
Številčenje:Vol. 25, iss. 20, art. 4647
PID:20.500.12556/RUL-134403 Povezava se odpre v novem oknu
UDK:616.858+616.831-003.8
ISSN pri članku:1420-3049
DOI:10.3390/molecules25204647 Povezava se odpre v novem oknu
COBISS.SI-ID:32284931 Povezava se odpre v novem oknu
Datum objave v RUL:13.01.2022
Število ogledov:765
Število prenosov:160
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:12.10.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:kurkumin, hidroksicinamska kislina, prion protein, amiloidna transformacija, Parkinsonova bolezen, nevrodegenerativne bolezni

Projekti

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Russian Foundation for Basic Research
Številka projekta:19-34-80004

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0208
Naslov:Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:BI-RU/19-20-040

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