Natural and synthetic derivatives of hydroxycinnamic acid modulating the pathological transformation of amyloidogenic proteins

Muronetz, Vladimir I. (avtor), Barinova, Kseniya (avtor), Kudryavtseva, Sofia (avtor), Medvedeva, Maria (avtor), Melnikova, Aleksandra (avtor), Sevostyanova, Irina (avtor), Semenyuk, Pavel (avtor), Stroylova, Yulia (avtor), Sova, Matej (avtor)

This review presents the main properties of hydroxycinnamic acid (HCA) derivatives and their potential application as agents for the prevention and treatment of neurodegenerative diseases. It is partially focused on the successful use of these compounds as inhibitors of amyloidogenic transformation of proteins. Firstly, the prerequisites for the emergence of interest in HCA derivatives, including natural compounds, are described. A separate section is devoted to synthesis and properties of HCA derivatives. Then, the results of molecular modeling of HCA derivatives with prion protein as well as with α-synuclein fibrils are summarized, followed by detailed analysis of the experiments on the effect of natural and synthetic HCA derivatives, as well as structurally similar phenylacetic and benzoic acid derivatives, on the pathological transformation of prion protein and α-synuclein. The ability of HCA derivatives to prevent amyloid transformation of some amyloidogenic proteins, and their presence not only in food products but also as natural metabolites in human blood and tissues, makes them promising for the prevention and treatment of neurodegenerative diseases of amyloid nature.

• Jezik: Angleški jezik
• Ključne besede: neurodegenerative diseases, curcumin, derivatives of hydroxycinnamic acid, amyloid, α-synuclein, prion protein, amyloid fibrils, prevention of amyloid transformation, Parkinson's disease
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 28 str.
• Številčenje: Vol. 25, iss. 20, art. 4647
• PID: 20.500.12556/RUL-134403
• UDK: 616.858+616.831-003.8
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules25204647
• COBISS.SI-ID: 32284931
• Datum objave v RUL: 13.01.2022

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 12.10.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: kurkumin, hidroksicinamska kislina, prion protein, amiloidna transformacija, Parkinsonova bolezen, nevrodegenerativne bolezni