Effect of high-dose intravenous vitamin C on postpartum oxidative stress in severe preeclampsia

Korenč, Monika (avtor), Osredkar, Joško (avtor), Geršak, Ksenija (avtor), Kumer, Kristina (avtor), Fabjan, Teja (avtor), Šterpin, Saša (avtor), Lučovnik, Miha (avtor)

Purpose: To determine whether high-dose intravenous vitamin C reduces oxidative stress in patients with severe preeclampsia in the first days postpartum. Methods: Biomarkers of oxidative stress were assessed as secondary outcomes of a single-center, randomized, placebo-controlled trial. Thirty-four patients with singleton pregnancies complicated by severe features of preeclampsia were randomized into two groups: intravenous vitamin C (1.5 g/6 h) (n = 17) or placebo (n = 17). Urinary concentrations of dityrosine, 8-hydroxy-2-deoxyguanosine (8-OHdg), 8-isoprostane, and N epsilon-(hexanoyl) lysine (HEL) were measured at days one and three after delivery and normalized for urinary creatinine in 22 of patients included (12 in vitamin C and 10 in placebo group). The Mann–Whitney U-test was used to compare values of oxidative stress biomarkers at days one and three after delivery in vitamin C vs. placebo groups (p ≤ 0.05 significant). Results: Dityrosine and 8-OHdg values did not differ significantly between the two study groups at day one after delivery (p = 0.23 and p = 0.77, respectively), but were significantly lower in the vitamin C group compared to the placebo group at day three after delivery (p = 0.04 and p = 0.03, respectively). Values of 8-isoprostane and HEL did not differ significantly between the two study groups at day one (p = 0.41 and p = 0.42, respectively), as well as at day three, after delivery (p = 0.25 and p = 0.24, respectively). Conclusion: High-dose intravenous vitamin C treatments in patients with severe preeclampsia reduced urinary levels of dityrosine and 8-OHdg (markers of protein and DNA oxidative damage, respectively) on day three after delivery. Vitamin C treatment had no significant effect on lipid peroxidation biomarkers, i.e., 8-isoprostane and HEL.

• Jezik: Angleški jezik
• Ključne besede: ascorbic acid, oxidative stress, preeclampsia, vitamin C
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: Str. 122-131
• Številčenje: Vol. 1, iss. 2
• PID: 20.500.12556/RUL-134352
• UDK: 577.16:618.3-00+612.015
• ISSN pri članku: 2673-3897
• DOI: 10.3390/reprodmed1020009
• COBISS.SI-ID: 27339779
• Datum objave v RUL: 10.01.2022

Gradivo je del revije

• Naslov: Reproductive medicine
• Skrajšan naslov: Reprod. med.
• Založnik: MDPI
• ISSN: 2673-3897
• COBISS.SI-ID: 27336707

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.09.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: nosečnostna toksemija, oksidativni stres, vitamini

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Ljubljana
• Številka projekta: 20170031/ 339 99 06 93

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0124
• Naslov: Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III