20.500.12556/RUL-134352 Effect of high-dose intravenous vitamin C on postpartum oxidative stress in severe preeclampsia Purpose: To determine whether high-dose intravenous vitamin C reduces oxidative stress in patients with severe preeclampsia in the first days postpartum. Methods: Biomarkers of oxidative stress were assessed as secondary outcomes of a single-center, randomized, placebo-controlled trial. Thirty-four patients with singleton pregnancies complicated by severe features of preeclampsia were randomized into two groups: intravenous vitamin C (1.5 g/6 h) (n = 17) or placebo (n = 17). Urinary concentrations of dityrosine, 8-hydroxy-2-deoxyguanosine (8-OHdg), 8-isoprostane, and N epsilon-(hexanoyl) lysine (HEL) were measured at days one and three after delivery and normalized for urinary creatinine in 22 of patients included (12 in vitamin C and 10 in placebo group). The Mann–Whitney U-test was used to compare values of oxidative stress biomarkers at days one and three after delivery in vitamin C vs. placebo groups (p ≤ 0.05 significant). Results: Dityrosine and 8-OHdg values did not differ significantly between the two study groups at day one after delivery (p = 0.23 and p = 0.77, respectively), but were significantly lower in the vitamin C group compared to the placebo group at day three after delivery (p = 0.04 and p = 0.03, respectively). Values of 8-isoprostane and HEL did not differ significantly between the two study groups at day one (p = 0.41 and p = 0.42, respectively), as well as at day three, after delivery (p = 0.25 and p = 0.24, respectively). Conclusion: High-dose intravenous vitamin C treatments in patients with severe preeclampsia reduced urinary levels of dityrosine and 8-OHdg (markers of protein and DNA oxidative damage, respectively) on day three after delivery. Vitamin C treatment had no significant effect on lipid peroxidation biomarkers, i.e., 8-isoprostane and HEL. ascorbic acid oxidative stress preeclampsia vitamin C nosečnostna toksemija oksidativni stres vitamini true false true Angleški jezik Slovenski jezik Članek v reviji 2022-01-10 12:49:26 2022-01-10 12:49:33 2026-09-14 14:32:53 0000-00-00 00:00:00 2020 0 0 Str. 122-131 iss. 2 Vol. 1 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.16:618.3-00+612.015 2673-3897 10.3390/reprodmed1020009 27339779 RAZ_Korenc_Monika_2020.pdf RAZ_Korenc_Monika_2020.pdf 1 A00353BDDC5A6B390C990538278D65B6 33c750a92c48c6f3b462e8cdbd6a6d27149b3fe07ce99c9431e217782b48dbcd 8ed6a6ee-720b-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152755 https://www.mdpi.com/2673-3897/1/2/9 1 33d963ae-720b-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152754 Medicinska fakulteta 0 0 0