izpis_h1_title_alt

Nuclear Quadrupole Resonance (NQR) : a useful spectroscopic tool in pharmacy for the study of polymorphism
ID Trontelj, Zvonko (Avtor), ID Pirnat, Janez (Avtor), ID Jazbinšek, Vojko (Avtor), ID Lužnik, Janko (Avtor), ID Srčič, Stanko (Avtor), ID Lavrič, Zoran (Avtor), ID Beguš, Samo (Avtor), ID Apih, Tomaž (Avtor), ID Žagar, Veselko (Avtor), ID Seliger, Janez (Avtor)

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Izvleček
Nuclear Quadrupole Resonance (NQR) spectroscopy has been known for 70 years. It is suitable for the study of measured (poly)crystalline chemical compounds containing quadrupole nuclei (nuclei with spin I ≥ 1) where the characteristic NQR frequencies represent the fingerprints of these compounds. In several cases, $^{14}$N NQR can distinguish between the polymorphic crystalline phases of active pharmaceutical ingredients (APIs). In order to further stimulate $^{14}$N NQR studies, we review here several results of API polymorphism studies obtained in Ljubljana laboratories: (a) In sulfanilamide, a clear distinction between three known polymorphs (α, β, γ) was demonstrated. (b) In famotidine, the full spectra of all seven different nitrogen positions were measured; two polymorphs were distinguished. (c) In piroxicam, the $^{14}$N NQR data helped in confirming the new polymorphic form V. (d) The compaction pressure in the tablet production of paracetamol, which is connected with linewidth change, can be used to distinguish between producers of paracetamol. We established that paracetamol in the tablets of six different manufacturers can be identified by $^{14}$N NQR linewidth. (e) Finally, in order to get an extremely sensitive $^{14}$N NQR spectrometer, the optical detection of the $^{14}$N NQR signal is mentioned.

Jezik:Angleški jezik
Ključne besede:NQR, Nuclear Quadrupole Resonance spectroscopy, $^{14}$N NQR, relaxation, drug polymorphism, crystal polymorphism, X-ray powder diffraction (XRPD), powder mixture quantification, NQR with optically pumped magnetometer
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
FE - Fakulteta za elektrotehniko
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:22 str.
Številčenje:Vol. 10, iss. 6, art. 450
PID:20.500.12556/RUL-133626 Povezava se odpre v novem oknu
UDK:53:543.42
ISSN pri članku:2073-4352
DOI:10.3390/cryst10060450 Povezava se odpre v novem oknu
COBISS.SI-ID:17705475 Povezava se odpre v novem oknu
Datum objave v RUL:06.12.2021
Število ogledov:610
Število prenosov:166
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Crystals
Skrajšan naslov:Crystals
Založnik:MDPI
ISSN:2073-4352
COBISS.SI-ID:36677893 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.06.2020

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P2-0250
Naslov:Metrologija in biometrični sistemi

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J7-9704
Naslov:JKR – nedekstruktivna metoda za študij in spremljanje polimorfizma v heterogenih farmacevtskih sistemih

Financer:EC - European Commission
Program financ.:FP7
Številka projekta:261670
Naslov:Counterfeit Pharmaceuticals Interception using Radiofrequency Methods in Realtime
Akronim:CONPHIRMER

Financer:Drugi - Drug financer ali več financerjev
Program financ.:MORS
Številka projekta:RR−07−011

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