Nuclear Quadrupole Resonance (NQR) : a useful spectroscopic tool in pharmacy for the study of polymorphism

Trontelj, Zvonko (avtor), Pirnat, Janez (avtor), Jazbinšek, Vojko (avtor), Lužnik, Janko (avtor), Srčič, Stanko (avtor), Lavrič, Zoran (avtor), Beguš, Samo (avtor), Apih, Tomaž (avtor), Žagar, Veselko (avtor), Seliger, Janez (avtor)

Nuclear Quadrupole Resonance (NQR) spectroscopy has been known for 70 years. It is suitable for the study of measured (poly)crystalline chemical compounds containing quadrupole nuclei (nuclei with spin I ≥ 1) where the characteristic NQR frequencies represent the fingerprints of these compounds. In several cases, $^{14}$N NQR can distinguish between the polymorphic crystalline phases of active pharmaceutical ingredients (APIs). In order to further stimulate $^{14}$N NQR studies, we review here several results of API polymorphism studies obtained in Ljubljana laboratories: (a) In sulfanilamide, a clear distinction between three known polymorphs (α, β, γ) was demonstrated. (b) In famotidine, the full spectra of all seven different nitrogen positions were measured; two polymorphs were distinguished. (c) In piroxicam, the $^{14}$N NQR data helped in confirming the new polymorphic form V. (d) The compaction pressure in the tablet production of paracetamol, which is connected with linewidth change, can be used to distinguish between producers of paracetamol. We established that paracetamol in the tablets of six different manufacturers can be identified by $^{14}$N NQR linewidth. (e) Finally, in order to get an extremely sensitive $^{14}$N NQR spectrometer, the optical detection of the $^{14}$N NQR signal is mentioned.

• Jezik: Angleški jezik
• Ključne besede: NQR, Nuclear Quadrupole Resonance spectroscopy, $^{14}$N NQR, relaxation, drug polymorphism, crystal polymorphism, X-ray powder diffraction (XRPD), powder mixture quantification, NQR with optically pumped magnetometer
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 22 str.
• Številčenje: Vol. 10, iss. 6, art. 450
• PID: 20.500.12556/RUL-133626
• UDK: 53:543.42
• ISSN pri članku: 2073-4352
• DOI: 10.3390/cryst10060450
• COBISS.SI-ID: 17705475
• Datum objave v RUL: 06.12.2021

Gradivo je del revije

• Naslov: Crystals
• Skrajšan naslov: Crystals
• Založnik: MDPI
• ISSN: 2073-4352
• COBISS.SI-ID: 36677893

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.06.2020