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Electronic emulator of biological tissue as an electrical load during electroporation
ID
Pirc, Eva
(
Avtor
),
ID
Balosetti, Bertrand
(
Avtor
),
ID
Miklavčič, Damijan
(
Avtor
),
ID
Reberšek, Matej
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,29 MB)
MD5: 9A78FD59A453269FD53C429310C80309
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-3417/10/9/3103
Galerija slik
Izvleček
Electroporation is an emerging technology, with great potential in many different medical and biotechnological applications, food engineering and biomass processing. Large variations of biological load characteristics, however, represent a great challenge in electroporator design, which results in different solutions. Because a clinical electroporator is a medical device, it must comply with medical device regulative and standards. However, none of the existing standards directly address the operation or electroporator’s performance requirements. In order to evaluate clinical, laboratory and prototype electroporation devices during the development process, or to evaluate their final performance considering at least from the perspective of output pulse parameters, we present a case study on the design of an electronic emulator of biological tissue as an electrical load during electroporation. The proposed electronic load emulator is a proof of concept, which enables constant and sustainable testing and unbiased comparison of different electroporators’ operations. We developed an analog electrical circuit that has equivalent impedance to the beef liver tissue in combination with needle electrodes, during high voltage pulse delivery and/or electroporation. Current and voltage measurements during electroporation of beef liver tissue ex vivo, were analyzed and parametrized to define the analog circuit equation. An equivalent circuit was simulated, built and validated. The proposed concept of an electronic load emulator can be used for “classical” electroporator (i.e., not nanosecond) performance evaluation and comparison of their operation. Additionally, it facilitates standard implementation regarding the testing protocol and enables quality assurance.
Jezik:
Angleški jezik
Ključne besede:
electroporation
,
tissue conductivity change
,
standard nonlinear load
,
biological load
,
electroporation emulator
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FE - Fakulteta za elektrotehniko
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
15 str.
Številčenje:
Vol. 10, iss. 9, art. 3103
PID:
20.500.12556/RUL-133368
UDK:
602.621
ISSN pri članku:
2076-3417
DOI:
10.3390/app10093103
COBISS.SI-ID:
13261059
Datum objave v RUL:
24.11.2021
Število ogledov:
752
Število prenosov:
147
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Applied sciences
Skrajšan naslov:
Appl. sci.
Založnik:
MDPI
ISSN:
2076-3417
COBISS.SI-ID:
522979353
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.05.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
elektroporacija
,
sprememba prevodnosti tkiva
,
standardno nelinearno breme
,
biološko breme
,
emulator elektroporacije
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
I0-0022
Naslov:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P2-0249
Naslov:
Elektroporacija v biologiji, biotehnologiji in medicini
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:
Junior Researchers
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