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An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases
ID Pogačnik da Silva, Lea (Avtor), ID Ota, Ajda (Avtor), ID Poklar Ulrih, Nataša (Avtor)

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Izvleček
Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

Jezik:Angleški jezik
Ključne besede:dietary phytochemicals, endogenous substances, mitochondrial dysfunction, neurodegenerative diseases, neuroinflammation, oxidative stress, protein fibrillation
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:25 str.
Številčenje:Vol. 9, iss. 3, art. 576
PID:20.500.12556/RUL-133217 Povezava se odpre v novem oknu
UDK:547.9:547.56:616.8
ISSN pri članku:2073-4409
DOI:10.3390/cells9030576 Povezava se odpre v novem oknu
COBISS.SI-ID:5172856 Povezava se odpre v novem oknu
Datum objave v RUL:17.11.2021
Število ogledov:1740
Število prenosov:153
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Cells
Skrajšan naslov:Cells
Založnik:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.03.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:prehrana, živila, naravne snovi, bioaktivne spojine, fenolne spojine, polifenoli, nevroprotektivne snovi, oksidativni stres, rastlinski ekstrakti, sadje, zelenjava, zeleni čaj, kurkumin, zdravilne učinkovine, nevrodegenerativne bolezni

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P4-0121
Naslov:Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi

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