An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases

Pogačnik da Silva, Lea (avtor), Ota, Ajda (avtor), Poklar Ulrih, Nataša (avtor)

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

• Jezik: Angleški jezik
• Ključne besede: dietary phytochemicals, endogenous substances, mitochondrial dysfunction, neurodegenerative diseases, neuroinflammation, oxidative stress, protein fibrillation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 25 str.
• Številčenje: Vol. 9, iss. 3, art. 576
• PID: 20.500.12556/RUL-133217
• UDK: 547.9:547.56:616.8
• ISSN pri članku: 2073-4409
• DOI: 10.3390/cells9030576
• COBISS.SI-ID: 5172856
• Datum objave v RUL: 17.11.2021

Gradivo je del revije

• Naslov: Cells
• Skrajšan naslov: Cells
• Založnik: MDPI
• ISSN: 2073-4409
• COBISS.SI-ID: 519958809

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.03.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: prehrana, živila, naravne snovi, bioaktivne spojine, fenolne spojine, polifenoli, nevroprotektivne snovi, oksidativni stres, rastlinski ekstrakti, sadje, zelenjava, zeleni čaj, kurkumin, zdravilne učinkovine, nevrodegenerativne bolezni

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0121
• Naslov: Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi