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CNL–Clitocybe nebularis lectin—the fungal GalNAcβ1-4GlcNAc-binding lectin
ID Sabotič, Jerica (Avtor), ID Kos, Janko (Avtor)

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Izvleček
Clitocybe nebularis lectin (CNL) is present in fruiting bodies of clouded agaric along with several similar isolectins that are all small and stable proteins. It is a beta-trefoil type lectin forming homodimers that are essential for its functionality. It binds specifically N,N′-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacDiNac) and human blood group A determinant-containing glycan epitopes. Its most probable function is to defend fruiting bodies against predators and parasites. In addition, an endogenous regulatory function is possible for CNL, as indicated by its interaction with fungal protease inhibitors sharing the beta-trefoil fold. CNL is toxic to insects, nematodes and amoebae, as well as to leukemic T-cell lines. Bivalent carbohydrate binding is essential for the toxicity of CNL, against both invertebrates and cancer-derived cell lines. In addition, CNL exhibits potent immunostimulation of human dendritic cells, resulting in a strong T helper cell type 1 response. Based on its unique characteristics, CNL is a promising candidate for applications in human and veterinary medicine as well as in agriculture, for plant protection.

Jezik:Angleški jezik
Ključne besede:beta-trefoil fold, LacDiNAc, entomotoxic, leukemic T-cell, antiproliferative, dendritic cell
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2019
Št. strani:10 str.
Številčenje:Vol. 24, iss. 23, art. 4204
PID:20.500.12556/RUL-133113 Povezava se odpre v novem oknu
UDK:577
ISSN pri članku:1420-3049
DOI:10.3390/molecules24234204 Povezava se odpre v novem oknu
COBISS.SI-ID:32898599 Povezava se odpre v novem oknu
Datum objave v RUL:11.11.2021
Število ogledov:584
Število prenosov:126
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.12.2019

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P4-0127
Naslov:Farmacevtska biotehnologija: znanost za zdravje

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