izpis_h1_title_alt

Characterization of biomarker levels in Crimean-Congo hemorrhagic fever and hantavirus fever with renal syndrome
ID Korva, Miša (Avtor), ID Resman Rus, Katarina (Avtor), ID Marušić, Miša (Avtor), ID Saksida, Ana (Avtor), ID Knap, Nataša (Avtor), ID Jelovšek, Mateja (Avtor), ID Strašek Smrdel, Katja (Avtor), ID Jakupi, Xhevat (Avtor), ID Humolli, Isme (Avtor), ID Dedushaj, Jusuf (Avtor), ID Petrovec, Miroslav (Avtor), ID Avšič-Županc, Tatjana (Avtor)

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Izvleček
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. The pathogenesis of both diseases is poorly understood, but it has been suggested that a host's immune mechanism might influence the pathogenesis of the diseases and survival. The aim of our study is to characterize cytokine response in patients with VHF in association with the disease progression and viral load. Forty soluble mediators of the immune response, coagulation, and endothelial dysfunction were measured in acute serum samples in 100 HFRS patients and 70 CCHF patients. HFRS and CCHF patients had significantly increased levels of IL-6, IL-12p70, IP-10, INF-γ, TNF-α, GM-CSF, MCP-3, and MIP-1b in comparison to the control group. Interestingly, HFRS patients had higher concentrations of serum MIP-1α, MIP-1β, which promote activation of macrophages and NK cells. HFRS patients had increased concentrations of IFN-γ and TNF-α, while CCHF patients had significantly higher concentrations of IFN-α and IL-8. In both, CCHF and HFRS patients' viral load significantly correlated with IP-10. Patients with fatal outcome had significantly elevated concentrations of IL-6, IFN-α2 and MIP-1α, while GRO-α, chemokine related to activation of neutrophils and basophils, was downregulated. Our study provided a comprehensive characterization of biomarkers released in the acute stages of CCHF and HFRS.

Jezik:Angleški jezik
Ključne besede:Crimean-Congo hemorrhagic fever, hantavirus fever, biomarkers, VHF, CCHF, HFRS, cytokines
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2019
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:19 str.
Številčenje:Vol. 11, iss. 8, art. 686
UDK:616.9
ISSN pri članku:1999-4915
DOI:10.3390/v11080686 Povezava se odpre v novem oknu
COBISS.SI-ID:34443481 Povezava se odpre v novem oknu
Datum objave v RUL:05.11.2021
Število ogledov:195
Število prenosov:70
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Viruses
Skrajšan naslov:Viruses
Založnik:MDPI
ISSN:1999-4915
COBISS.SI-ID:517597977 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.08.2019

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:krimsko-kongoška hemoragična mrzlica, hantavirusna mrzlica, biomarkerji

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0083
Naslov:Odnosi parazitskega obstajanja

Financer:EC - European Commission
Program financ.:H2020
Številka projekta:653316
Naslov:European Virus Archive goes global
Akronim:EVAg

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