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Association of uremic toxins and inflammatory markers with physical performance in dialysis patients
ID
Pajek, Maja
(
Avtor
),
ID
Jerman, Alexander
(
Avtor
),
ID
Osredkar, Joško
(
Avtor
),
ID
Buturović-Ponikvar, Jadranka
(
Avtor
),
ID
Pajek, Jernej
(
Avtor
)
PDF - Predstavitvena datoteka,
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(269,33 KB)
MD5: 56637FEFB7C129295F5561BAE4B84E4D
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2072-6651/10/10/403
Galerija slik
Izvleček
Association of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, with low comorbidity to reduce the potential confounding of concomitant disease. Midweek pre-dialysis serum levels of asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, and urea were analyzed as predictor parameters of physical performance measures in adjusted models. Serum levels of most measured toxins were not significantly related to performance, except for ADMA, which was significantly related to poorer performance in the STS-10 test (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP was associated with poorer results in the 6MWT (B = −2.6 ± 0.97 m, p < 0.01) and a lower HAP score (B = −0.36 ± 0.14, p = 0.01). There were no other significant associations found. We conclude that inflammation may be a more important pathway to physical impediment than uremic toxemia. This suggests that there is a large physical rehabilitation potential in non-inflamed uremic patients.
Jezik:
Angleški jezik
Ključne besede:
hemodialysis
,
6-minute walk test
,
sit-to-stand test
,
handgrip strength
,
Human Activity Profile
,
sarcopenia
,
muscle
,
asymmetric dimethyl-arginine
,
C-reactive protein
,
motor ability
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FŠ - Fakulteta za šport
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2018
Št. strani:
12 str.
Številčenje:
Vol. 10, iss. 10, art. 403
PID:
20.500.12556/RUL-132072
UDK:
616.61-78:616-074
ISSN pri članku:
2072-6651
DOI:
10.3390/toxins10100403
COBISS.SI-ID:
4610417
Datum objave v RUL:
11.10.2021
Število ogledov:
1046
Število prenosov:
167
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Objavi na:
Gradivo je del revije
Naslov:
Toxins
Skrajšan naslov:
Toxins
Založnik:
MDPI
ISSN:
2072-6651
COBISS.SI-ID:
517594649
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.10.2018
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0323
Naslov:
Ledvične bolezni in nadomestna zdravljenja
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
University Medical Centre Ljubljana
Številka projekta:
20150204
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