Association of uremic toxins and inflammatory markers with physical performance in dialysis patients

Pajek, Maja (avtor), Jerman, Alexander (avtor), Osredkar, Joško (avtor), Buturović-Ponikvar, Jadranka (avtor), Pajek, Jernej (avtor)

Association of higher serum levels of uremic toxins and inflammatory markers with poorer physical performance is understudied. We measured the six-minute walk test (6MWT), 10 repetition sit-to-stand test (STS-10), handgrip strength (HGS), and Human Activity Profile (HAP) questionnaire score in 90 prevalent hemodialysis patents, with low comorbidity to reduce the potential confounding of concomitant disease. Midweek pre-dialysis serum levels of asymmetric dimethyl-arginine (ADMA), β2-microglobulin (B2M), high-sensitivity C-reactive protein (hs-CRP), indoxyl sulfate (IS), insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), myostatin, and urea were analyzed as predictor parameters of physical performance measures in adjusted models. Serum levels of most measured toxins were not significantly related to performance, except for ADMA, which was significantly related to poorer performance in the STS-10 test (B = 0.11 ± 0.03 s, p < 0.01). Higher hs-CRP was associated with poorer results in the 6MWT (B = −2.6 ± 0.97 m, p < 0.01) and a lower HAP score (B = −0.36 ± 0.14, p = 0.01). There were no other significant associations found. We conclude that inflammation may be a more important pathway to physical impediment than uremic toxemia. This suggests that there is a large physical rehabilitation potential in non-inflamed uremic patients.

• Jezik: Angleški jezik
• Ključne besede: hemodialysis, 6-minute walk test, sit-to-stand test, handgrip strength, Human Activity Profile, sarcopenia, muscle, asymmetric dimethyl-arginine, C-reactive protein, motor ability
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FŠ - Fakulteta za šport
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2018
• Št. strani: 12 str.
• Številčenje: Vol. 10, iss. 10, art. 403
• PID: 20.500.12556/RUL-132072
• UDK: 616.61-78:616-074
• ISSN pri članku: 2072-6651
• DOI: 10.3390/toxins10100403
• COBISS.SI-ID: 4610417
• Datum objave v RUL: 11.10.2021

Gradivo je del revije

• Naslov: Toxins
• Skrajšan naslov: Toxins
• Založnik: MDPI
• ISSN: 2072-6651
• COBISS.SI-ID: 517594649

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.10.2018

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0323
• Naslov: Ledvične bolezni in nadomestna zdravljenja

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Ljubljana
• Številka projekta: 20150204