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Novel spray dried glycerol 2-phosphate cross-linked chitosan microparticulate vaginal delivery system-development, characterization and cytotoxicity studies
ID
Szymańska, Emilia
(
Author
),
ID
Szekalska, M.
(
Author
),
ID
Czarnomysy, Robert
(
Author
),
ID
Lavrič, Zoran
(
Author
),
ID
Srčič, Stanko
(
Author
),
ID
Miltyk, Wojciech
(
Author
),
ID
Winnicka, K.
(
Author
)
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MD5: 8A213E6543A2D2A37D20F3470BC7AD8D
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http://www.mdpi.com/1660-3397/14/10/174
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Abstract
Chitosan microparticulate delivery systems containing clotrimazole were prepared by a spray drying technique using glycerol 2-phosphate as an ion cross-linker. The impact of a cross-linking ratio on microparticle characteristics was evaluated. Drug-free and drug-loaded unmodified or ion cross-linked chitosan microparticles were examined for the in vitro cytotoxicity in VK2/E6E7 human vaginal epithelial cells. The presence of glycerol 2-phosphate influenced drug loading and encapsulation efficacy in chitosan microparticles. By increasing the cross-linking ratio, the microparticles with lower diameter, moisture content and smoother surface were observed. Mucoadhesive studies displayed that all formulations possessed mucoadhesive properties. The in vitro release profile of clotrimazole was found to alter considerably by changing the glycerol 2-phosphate/chitosan ratio. Results from cytotoxicity studies showed occurrence of apoptotic cells in the presence of chitosan and ion cross-linked chitosan microparticles, followed by a loss of membrane potential suggesting that cell death might go through the mitochondrial apoptotic pathway.
Language:
English
Keywords:
chitosan
,
microparticles
,
glycerol 2-phosphate
,
spray drying
,
mucoadhesiveness
,
cytotoxicity
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2016
Number of pages:
22 str.
Numbering:
Vol. 14, iss. 10, art. 174
PID:
20.500.12556/RUL-131509
UDC:
577.1
ISSN on article:
1660-3397
DOI:
10.3390/md14100174
COBISS.SI-ID:
4190065
Publication date in RUL:
29.09.2021
Views:
4233
Downloads:
152
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Record is a part of a journal
Title:
Marine drugs
Shortened title:
Mar. drugs
Publisher:
MDPI
ISSN:
1660-3397
COBISS.SI-ID:
23578841
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.10.2016
Secondary language
Language:
Slovenian
Keywords:
hitosan
,
mikrodelci
,
citotoksičnost
,
dostavni sistem
,
glicerol 2-fosfat
Projects
Funder:
Other - Other funder or multiple funders
Funding programme:
Medical University of Białystok
Project number:
N/ST/ZB/16/006/2215
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