Supercritical carbon dioxide extraction of four medicinal mediterranean plants : investigation of chemical composition and antioxidant activity
Čižmek, Lara (Author), Bavcon Kralj, Mojca (Author), Čož-Rakovac, Rozelindra (Author), Mazur, Dmitry M. (Author), Ul'yanovskii, Nikolai (Author), Likon, Marko (Author), Trebše, Polonca (Author)

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With everyday advances in the field of pharmaceuticals, medicinal plants have high priority regarding the introduction of novel synthetic compounds by the usage of environmentally friendly extraction technologies. Herein, a supercritical CO2 extraction method was implemented in the analysis of four plants (chamomile, St. John’s wort, yarrow, and curry plant) after which the non-targeted analysis of the chemical composition, phenolic content, and antioxidant activity was evaluated. The extraction yield was the highest for the chamomile (5%), while moderate yields were obtained for the other three plants. The chemical composition analyzed by gas chromatographyhigh-resolution mass spectrometry (GC-HRMS) and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) demonstrated extraction of diverse compounds including terpenes and terpenoids, fatty acids, flavonoids and coumarins, functionalized phytosterols, and polyphenols. Voltammetry of microfilm immobilized on a glassy carbon electrode using square-wave voltammetry (SWV) was applied in the analysis of extracts. It was found that antioxidant activity obtained by SWV correlates well to 1,1-diphenyl-2-picrylhidrazine (DPPH) radical assay (R2 = 0.818) and ferric reducing antioxidant power (FRAP) assay (R2 = 0.640), but not to the total phenolic content (R 2 = 0.092). Effective results were obtained in terms of activity showing the potential usage of supercritical CO2 extraction to acquire bioactive compounds of interest.

Keywords:green solvents, chamomile, yarrow, St. John's wort, curry plant, square-wave voltammetry, chromatography
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:ZF - University College of Health Studies
Number of pages:Str. 1-18
Numbering:Vol. 26, iss. 18
ISSN on article:1420-3049
DOI:10.3390/ molecules26185697 This link opens in a new window
COBISS.SI-ID:77584387 This link opens in a new window
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Record is a part of a journal

Shortened title:Molecules
COBISS.SI-ID:18462981 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:J2-8162
Name:Zapiranje snovnih poti pri čiščenju komunalnih odpadnih voda z zelenimi tehnologijami

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P3-0388
Name:Mehanizmi varovanja zdravja


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:20.09.2021

Secondary language

Keywords:zelena topila, kamilica, rman, šentjanževka, curry, voltametrija s kvadratnimi valovi, kromatografija

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