Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in Slovenia

Korva, Miša (avtor), Knap, Nataša (avtor), Resman Rus, Katarina (avtor), Fajs, Luka (avtor), Grubelnik, Gašper (avtor), Bremec, Matejka (avtor), Knapič, Tea (avtor), Trilar, Tomi (avtor), Avšič-Županc, Tatjana (avtor)

Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus-Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus),M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava-Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.

• Jezik: Angleški jezik
• Ključne besede: hantavirus, Slovenia, epidemiology, genetic diversity, phylogeography
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2013
• Št. strani: Str. 3071-3087
• Številčenje: Vol. 5, iss. 12
• PID: 20.500.12556/RUL-129243
• UDK: 616.9
• ISSN pri članku: 1999-4915
• DOI: 10.3390/v5123071
• COBISS.SI-ID: 31054553
• Datum objave v RUL: 31.08.2021

Gradivo je del revije

• Naslov: Viruses
• Skrajšan naslov: Viruses
• Založnik: MDPI
• ISSN: 1999-4915
• COBISS.SI-ID: 517597977

Licence

• Licenca: CC BY 3.0, Creative Commons Priznanje avtorstva 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by/3.0/deed.sl
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• Začetek licenciranja: 10.12.2013

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: hantavirus, Slovenija, epidemiologija, genske raznolikosti

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0083
• Naslov: Odnosi parazitskega obstajanja

• Financer: EC - European Commission
• Program financ.: FP7
• Številka projekta: 228292
• Naslov: European Virus Archive
• Akronim: EVA