Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in Slovenia

Korva, Miša (author), Knap, Nataša (author), Resman Rus, Katarina (author), Fajs, Luka (author), Grubelnik, Gašper (author), Bremec, Matejka (author), Knapič, Tea (author), Trilar, Tomi (author), Avšič-Županc, Tatjana (author)

Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus-Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus),M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava-Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.

• Language: English
• Keywords: hantavirus, Slovenia, epidemiology, genetic diversity, phylogeography
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2013
• Number of pages: Str. 3071-3087
• Numbering: Vol. 5, iss. 12
• PID: 20.500.12556/RUL-129243
• UDC: 616.9
• ISSN on article: 1999-4915
• DOI: 10.3390/v5123071
• COBISS.SI-ID: 31054553
• Publication date in RUL: 31.08.2021

Record is a part of a journal

• Title: Viruses
• Shortened title: Viruses
• Publisher: MDPI
• ISSN: 1999-4915
• COBISS.SI-ID: 517597977

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
• Licensing start date: 10.12.2013

Secondary language

• Language: Slovenian
• Keywords: hantavirus, Slovenija, epidemiologija, genske raznolikosti

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0083
• Name: Odnosi parazitskega obstajanja

• Funder: EC - European Commission
• Funding programme: FP7
• Project number: 228292
• Name: European Virus Archive
• Acronym: EVA