20.500.12556/RUL-129243 Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in Slovenia Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus-Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus),M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava-Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas. hantavirus Slovenia epidemiology genetic diversity phylogeography hantavirus Slovenija epidemiologija genske raznolikosti true false true Angleški jezik Slovenski jezik Članek v reviji 2021-08-31 09:11:41 2021-08-31 09:11:44 2022-09-08 04:07:28 0000-00-00 00:00:00 2013 0 0 Str. 3071-3087 iss. 12 Vol. 5 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 1999-4915 10.3390/v5123071 31054553 RAZ_Korva_Misa_2013.pdf RAZ_Korva_Misa_2013.pdf 1 548E156FC9D8F7EF0B15A2CBDEC74F51 033eb2a05c45faab5f4041bed4215af239ed19466e81d27426303365219f9566 b2e0346a-0a2a-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146206 http://www.mdpi.com/1999-4915/5/12/3071 1 79036cae-0a2a-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146205 Medicinska fakulteta 0 0 0