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Methods for studying endocytotic pathways of herpesvirus encoded G protein-coupled receptors
ID Mavri, Maša (Avtor), ID Spiess, Katja (Avtor), ID Rosenkilde, Mette Marie (Avtor), ID Rutland, Catrin Sian (Avtor), ID Vrecl, Milka (Avtor), ID Kubale, Valentina (Avtor)

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Izvleček
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled receptors (GPCRs) constitute a family of receptors with seven transmembrane alpha-helical domains (7TM receptors) expressed at the cell surface, where they regulate physiological and pathological cellular processes. Several herpesviruses encode receptors (vGPCRs) which benefits the virus by avoiding host immune surveillance, supporting viral dissemination, and thereby establishing widespread and lifelong infection, processes where receptor signaling and/or endocytosis seem central. vGPCRs are rising as potential drug targets as exemplified by the cytomegalovirus-encoded receptor US28, where its constitutive internalization has been exploited for selective drug delivery in virus infected cells. Therefore, studying GPCR trafficking is of great importance. This review provides an overview of the current knowledge of endocytic and cell localization properties of vGPCRs and methodological approaches used for studying receptor internalization. Using such novel approaches, we show constitutive internalization of the BILF1 receptor from human and porcine γ-1 herpesviruses and present motifs from the eukaryotic linear motif (ELM) resources with importance for vGPCR endocytosis.

Jezik:Angleški jezik
Ključne besede:endocytosis, G-protein coupled receptors, herpesvirus, methods, Herpesviridae
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:23 str.
Številčenje:Vol. 25, iss. 23, art. 5710
UDK:636.09:616
ISSN pri članku:1420-3049
DOI:10.3390/molecules25235710 Povezava se odpre v novem oknu
COBISS.SI-ID:40808963 Povezava se odpre v novem oknu
Datum objave v RUL:04.08.2021
Število ogledov:276
Število prenosov:73
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:03.12.2020

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:PhD funding

Financer:Drugi - Drug financer ali več financerjev
Program financ.:COST
Številka projekta:CA 18133
Akronim:ERNEST

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