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In vitro comparison of the bioactivities of Japanese and Bohemian knotweed ethanol extracts
ID
Pogačnik da Silva, Lea
(
Avtor
),
ID
Bergant, Tina
(
Avtor
),
ID
Skrt, Mihaela
(
Avtor
),
ID
Poklar Ulrih, Nataša
(
Avtor
),
ID
Viktorová, Jitka
(
Avtor
),
ID
Ruml, Tomáš
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,13 MB)
MD5: C1A96AA454D4184724EF77285FD7FF42
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2304-8158/9/5/544
Galerija slik
Izvleček
Knotweed is a flowering plant that is native to temperate and subtropical regions in the northern hemisphere. We evaluated Japanese (Reynoutria japonica Houtt.) and Bohemian (Fallopia x bohemica) knotweed rhizome and flower ethanol extracts and compared them in terms of their biological activities. The specific polyphenols were identified and quantified using HPLC/DAD, and the antioxidant activity was determined using 2,2-diphenly-1-picrylhydrazyl (DPPH) and cellular antioxidant capacity assays. The anticancer activity was evaluated as the difference between the cytotoxicity to cancer cells compared with control cells. The antimicrobial activity was determined using bacteria and yeast. The antidiabetic activity was tested as the ability of the extracts to inhibit α-amylase. Both rhizome extracts were sources of polyphenols, particularly polydatin and (−)-epicatechin; however, the cellular assay showed the highest antioxidant capacity in the flower extract of F. bohemica. The PaTu cell line was the least sensitive toward all knotweed extracts. The flower extracts of both species were less toxic than the rhizomes. However, the activity of the tested extracts was not specific for cancer cells, indicating a rather toxic mode of action. Furthermore, all used extracts decreased the α-amylase activity, and the rhizome extracts were more effective than the flower extracts. None of the extracts inhibited bacterial growth; however, they inhibited yeast growth. The results confirmed that rhizomes of Reynoutria japonica Houtt. could become a new source of bioactive compounds, which could be used for the co-treatment of diabetes and as antifungal agents.
Jezik:
Angleški jezik
Ključne besede:
antioxidant activity
,
cellular antioxidant activity
,
polyphenols
,
anticancer activity
,
antimicrobial activity
,
antidiabetic activity
,
herbal medicine
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
12 str.
Številčenje:
Vol. 9, iss. 5, art. 544
PID:
20.500.12556/RUL-128261
UDK:
577.1:547.9:582.665:547.56:579.24:66.094.3.097.8
ISSN pri članku:
2304-8158
DOI:
10.3390/foods9050544
COBISS.SI-ID:
13360899
Datum objave v RUL:
07.07.2021
Število ogledov:
1037
Število prenosov:
232
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Foods
Skrajšan naslov:
Foods
Založnik:
MDPI
ISSN:
2304-8158
COBISS.SI-ID:
512252472
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.05.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
antioksidativna učinkovitost
,
rastlinski izvlečki
,
dresnik
,
Fallopia
,
bioaktivne snovi
,
fenolne spojine
,
polifenoli
,
protimikrobno delovanje
,
protirakavo delovanje
,
antidiabetično delovanje
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0121
Naslov:
Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Technology Agency of the Czech Republic
Številka projekta:
TJ02000372
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