Healthy lifestyle recommendations : do the beneficial effects originate from NAD + amount at the cellular level?

Poljšak, Borut (avtor), Kovač, Vito (avtor), Milisav, Irina (avtor)

In this review, we describe the role of oxidized forms of nicotinamide adenine dinucleotide (NAD+ ) as a molecule central to health benefits as the result from observing selected healthy lifestyle recommendations. Namely, NAD+ level can be regulated by lifestyle and nutrition approaches such as fasting, caloric restriction, sports activity, low glucose availability, and heat shocks. NAD+ is reduced with age at a cellular, tissue, and organismal level due to inflammation, defect in NAMPT-mediated NAD+ biosynthesis, and the PARP-mediated NAD+ depletion. This leads to a decrease in cellular energy production and DNA repair and modifies genomic signalling leading to an increased incidence of chronic diseases and ageing. By implementing healthy lifestyle approaches, endogenous intracellular NAD+ levels can be increased, which explains the molecular mechanisms underlying health benefits at the organismal level. Namely, adherence to here presented healthy lifestyle approaches is correlated with an extended life expectancy free of major chronic diseases.

• Jezik: Angleški jezik
• Ključne besede: nicotinamide adenine dinucleotide, NAD+, health benefits, molecular mechanisms, healthy lifestyle
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: ZF - Zdravstvena fakulteta
• Leto izida: 2020
• Št. strani: Str. 1-12
• Številčenje: Vol. 2020
• PID: 20.500.12556/RUL-124548
• UDK: 612.68:613
• ISSN pri članku: 1942-0994
• DOI: 10.1155/2020/8819627
• COBISS.SI-ID: 49263107
• Datum objave v RUL: 01.02.2021

Gradivo je del revije

• Naslov: Oxidative medicine and cellular longevity
• Skrajšan naslov: Oxid. med. cell. longev.
• Založnik: Hindawi
• ISSN: 1942-0994
• COBISS.SI-ID: 29264601

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.02.2021

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0388
• Naslov: Mehanizmi varovanja zdravja