20.500.12556/RUL-124548 Healthy lifestyle recommendations do the beneficial effects originate from NAD + amount at the cellular level? In this review, we describe the role of oxidized forms of nicotinamide adenine dinucleotide (NAD+ ) as a molecule central to health benefits as the result from observing selected healthy lifestyle recommendations. Namely, NAD+ level can be regulated by lifestyle and nutrition approaches such as fasting, caloric restriction, sports activity, low glucose availability, and heat shocks. NAD+ is reduced with age at a cellular, tissue, and organismal level due to inflammation, defect in NAMPT-mediated NAD+ biosynthesis, and the PARP-mediated NAD+ depletion. This leads to a decrease in cellular energy production and DNA repair and modifies genomic signalling leading to an increased incidence of chronic diseases and ageing. By implementing healthy lifestyle approaches, endogenous intracellular NAD+ levels can be increased, which explains the molecular mechanisms underlying health benefits at the organismal level. Namely, adherence to here presented healthy lifestyle approaches is correlated with an extended life expectancy free of major chronic diseases. nicotinamide adenine dinucleotide NAD+ health benefits molecular mechanisms healthy lifestyle true false true Angleški jezik Angleški jezik Članek v reviji 2021-02-01 09:09:18 2021-02-01 09:09:19 2022-09-04 04:00:06 0000-00-00 00:00:00 2020 0 0 Str. 1-12 Vol. 2020 2020 0000-00-00 NiDoloceno NiDoloceno apc 0000-00-00 0000-00-00 0000-00-00 612.68:613 1942-0994 10.1155/2020/8819627 49263107 29264601 RAZ_Poljsak_Borut_2020.pdf RAZ_Poljsak_Borut_2020.pdf 1 C814726383F01C0B3E4036686BD9BD8A 0a4319c96f8495d3d151ad29267cf67d9a2eb613bd5d4f1c0f542659fcba6c1a 950e6aa4-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=140080 https://www.hindawi.com/journals/omcl/2020/8819627/ 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=140066 Zdravstvena fakulteta 0 0 0