izpis_h1_title_alt

A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems
Kopač, Tilen (Avtor), Krajnc, Matjaž (Avtor), Ručigaj, Aleš (Avtor)

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Izvleček
Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature and biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects in the mathematical model, prevailing especially in the field of low crosslink densities of TEMPO nanocellulose hydrogel in acid medium. Accordingly, alginate hydrogelswere subjected to the research as comparable samples with less significant hydrogel bonds effect. The equation was built upon the determination of the average mesh size in a TEMPO nanocellulose and alginate hydrogel network and studying its changes in different pH release environments. Based on rheological measurements of TEMPO nanocellulose and alginate from the basic and acidic release environment, the mechanism of swelling and shrinkage was thoroughly discussed as well as the influence of substituent groups, ionic interactions and hydrogen bonds in different pH medium were evaluated. Due to the protonation of carboxylic groups, TEMPO nanocellulose and alginate hydrogels shrink in an acid environment. The presented approach will accelerate, improve and reduce the cost of research in the field of controlled release technology with target drug delivery.

Jezik:Angleški jezik
Ključne besede:TEMPO nanocellulose, pH sensitive hydrogel, controlled drug delivery system
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Leto izida:2021
Št. strani:Str. 695-707
Številčenje:Vol. 168
UDK:661.728:620.3
ISSN pri članku:0141-8130
DOI:10.1016/j.ijbiomac.2020.11.126 Povezava se odpre v novem oknu
COBISS.SI-ID:40059651 Povezava se odpre v novem oknu
Število ogledov:278
Število prenosov:200
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:International journal of biological macromolecules
Skrajšan naslov:Int. j. biol. macromol.
Založnik:Elsevier
ISSN:0141-8130
COBISS.SI-ID:25637888 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P2-0191
Naslov:Kemijsko inženirstvo

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:02.12.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:TEMPO nanoceluloza, pH odzivni hidrogel, dostavni sistem učinkovin, kontrolirano sproščanje

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