A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems

Kopač, Tilen (avtor), Krajnc, Matjaž (avtor), Ručigaj, Aleš (avtor)

Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature and biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects in the mathematical model, prevailing especially in the field of low crosslink densities of TEMPO nanocellulose hydrogel in acid medium. Accordingly, alginate hydrogelswere subjected to the research as comparable samples with less significant hydrogel bonds effect. The equation was built upon the determination of the average mesh size in a TEMPO nanocellulose and alginate hydrogel network and studying its changes in different pH release environments. Based on rheological measurements of TEMPO nanocellulose and alginate from the basic and acidic release environment, the mechanism of swelling and shrinkage was thoroughly discussed as well as the influence of substituent groups, ionic interactions and hydrogen bonds in different pH medium were evaluated. Due to the protonation of carboxylic groups, TEMPO nanocellulose and alginate hydrogels shrink in an acid environment. The presented approach will accelerate, improve and reduce the cost of research in the field of controlled release technology with target drug delivery.

• Jezik: Angleški jezik
• Ključne besede: TEMPO nanocellulose, pH sensitive hydrogel, controlled drug delivery system
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: Str. 695-707
• Številčenje: Vol. 168
• PID: 20.500.12556/RUL-122254
• UDK: 661.728:620.3
• ISSN pri članku: 0141-8130
• DOI: 10.1016/j.ijbiomac.2020.11.126
• COBISS.SI-ID: 40059651
• Datum objave v RUL: 02.12.2020

Gradivo je del revije

• Naslov: International journal of biological macromolecules
• Skrajšan naslov: Int. j. biol. macromol.
• Založnik: Elsevier
• ISSN: 0141-8130
• COBISS.SI-ID: 25637888

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: TEMPO nanoceluloza, pH odzivni hidrogel, dostavni sistem učinkovin, kontrolirano sproščanje

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P2-0191
• Naslov: Kemijsko inženirstvo