Safety and feasibility of electrochemotherapy of the pancreas in a porcine model

Dežman, Rok (avtor), Čemažar, Maja (avtor), Serša, Gregor (avtor), Seliškar, Alenka (avtor), Erjavec, Vladimira (avtor), Trotovšek, Blaž (avtor), Gašljević, Gorana (avtor), Omerzel, Maša (avtor), Lampreht Tratar, Urša (avtor), Kos, Bor (avtor), Djokić, Mihajlo (avtor), Milevoj, Nina (avtor), Štukelj, Marina (avtor), Boc, Nina (avtor), Izlakar, Jani (avtor), Popović, Peter (avtor)

Objectives: The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed to evaluate the safety and feasibility of ECT of the pancreas in a porcine survival model. Methods: In the first group, 4 animals underwent computed tomography (CT)–guided percutaneous ECT with bleomycin of the pancreatic tail. In the second group (4 animals), the intraoperative ECTwith bleomycin of pancreatic tail and head was performed. Animals were followed for 7 days and then killed. Clinical parameters, CT imaging, laboratory, and histologic analysis were performed. Results: All pigs survived the ECT procedure and none of them developed clinical signs of acute pancreatitis or related complications. There were no signs of acute pancreatitis or damage to the large vessels present in the follow-up CT scans. No significant change in laboratory parameters was obtained after procedure. Conclusions: This study shows that ECT with bleomycin is feasible and safe in the pancreatic parenchyma. Clinical studies are needed to evaluate the efficacy of ECT in pancreatic cancer.

• Jezik: Angleški jezik
• Ključne besede: electrochemotherapy, electroporation, pancreas, porcine, pancreatic carcinoma, pancreatic fistula
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; ZF - Zdravstvena fakulteta ; VF - Veterinarska fakulteta ; FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: Str. 1168-1173
• Številčenje: Vol. 49, no. 9
• PID: 20.500.12556/RUL-122072
• UDK: 602.6/.7
• ISSN pri članku: 0885-3177
• DOI: 10.1097/MPA.0000000000001642
• COBISS.SI-ID: 28129539
• Datum objave v RUL: 19.11.2020

Gradivo je del revije

• Naslov: Pancreas
• Skrajšan naslov: Pancreas
• Založnik: Wolters Kluwer
• ISSN: 0885-3177
• COBISS.SI-ID: 512302617

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: elektrokemoterapija, elektroporacija, pankreas, rak trebušne slinavke, prašiči

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0003
• Naslov: Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev