20.500.12556/RUL-122072 Safety and feasibility of electrochemotherapy of the pancreas in a porcine model Objectives: The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed to evaluate the safety and feasibility of ECT of the pancreas in a porcine survival model. Methods: In the first group, 4 animals underwent computed tomography (CT)–guided percutaneous ECT with bleomycin of the pancreatic tail. In the second group (4 animals), the intraoperative ECTwith bleomycin of pancreatic tail and head was performed. Animals were followed for 7 days and then killed. Clinical parameters, CT imaging, laboratory, and histologic analysis were performed. Results: All pigs survived the ECT procedure and none of them developed clinical signs of acute pancreatitis or related complications. There were no signs of acute pancreatitis or damage to the large vessels present in the follow-up CT scans. No significant change in laboratory parameters was obtained after procedure. Conclusions: This study shows that ECT with bleomycin is feasible and safe in the pancreatic parenchyma. Clinical studies are needed to evaluate the efficacy of ECT in pancreatic cancer. electrochemotherapy electroporation pancreas porcine pancreatic carcinoma pancreatic fistula elektrokemoterapija elektroporacija pankreas rak trebušne slinavke prašiči true false true Angleški jezik Slovenski jezik Članek v reviji 2020-11-19 14:25:41 2020-11-19 14:25:44 2025-05-08 10:03:24 0000-00-00 00:00:00 2020 0 0 Str. 1168-1173 no. 9 Vol. 49 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.6/.7 0885-3177 10.1097/MPA.0000000000001642 28129539 safety_and_feasibility_of_electrochemotherapy_of.6_(2).pdf safety_and_feasibility_of_electrochemotherapy_of.6_(2).pdf 1 BD3B10F2D702D27FE2FD182A9BDA5C74 1a6ad658ceaa63a197a630bbf152dddf4b41dcd0c07236ce09870cd0036e3e6c 02dcaae7-146f-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=201482 https://journals.lww.com/pancreasjournal/fulltext/2020/10000/safety_and_feasibility_of_electrochemotherapy_of.6.aspx 0 0cea0853-2bde-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210153 Medicinska fakulteta Zdravstvena fakulteta Veterinarska fakulteta Fakulteta za elektrotehniko 0 0 0