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The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties
ID Kopač, Tilen (Avtor), ID Ručigaj, Aleš (Avtor), ID Krajnc, Matjaž (Avtor)

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Izvleček
Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.

Jezik:Angleški jezik
Ključne besede:TEMPO nanocellulose, mesh size, drug diffusion coefficient, controlled drug release, mathematical modelling
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:Str. 557-569
Številčenje:Vol. 159
PID:20.500.12556/RUL-116206 Povezava se odpre v novem oknu
UDK:678
ISSN pri članku:0141-8130
DOI:10.1016/j.ijbiomac.2020.05.088 Povezava se odpre v novem oknu
COBISS.SI-ID:15760387 Povezava se odpre v novem oknu
Datum objave v RUL:22.05.2020
Število ogledov:1018
Število prenosov:260
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:International journal of biological macromolecules
Skrajšan naslov:Int. j. biol. macromol.
Založnik:Elsevier
ISSN:0141-8130
COBISS.SI-ID:25637888 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:biopolimeri, hidrogeli, nanoceluloza, velikost mreže, matematično modeliranje

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P2-0191
Naslov:Kemijsko inženirstvo

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