izpis_h1_title_alt

The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties
Kopač, Tilen (Avtor), Ručigaj, Aleš (Avtor), Krajnc, Matjaž (Avtor)

.pdfPDF - Predstavitvena datoteka. Vsebina dokumenta nedostopna do 27.05.2021.
URLURL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0141813020332414 Povezava se odpre v novem oknu

Izvleček
Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.

Jezik:Angleški jezik
Ključne besede:TEMPO nanocellulose, mesh size, drug diffusion coefficient, controlled drug release, mathematical modelling
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Leto izida:2020
Št. strani:str. 1-43
Številčenje:Vol.
UDK:678
ISSN pri članku:0141-8130
DOI:10.1016/j.ijbiomac.2020.05.088 Povezava se odpre v novem oknu
COBISS.SI-ID:15760387 Povezava se odpre v novem oknu
Licenca:CC BY-NC-ND 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Število ogledov:72
Število prenosov:40
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:International journal of biological macromolecules
Skrajšan naslov:Int. j. biol. macromol.
Založnik:Butterworth Scientific Ltd
ISSN:0141-8130
COBISS.SI-ID:25637888 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Številka projekta:P2-0191
Naslov:Kemijsko inženirstvo

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:biopolimeri, hidrogeli, nanoceluloza, velikost mreže, matematično modeliranje

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj