20.500.12556/RUL-116206 The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties. TEMPO nanocellulose mesh size drug diffusion coefficient controlled drug release mathematical modelling biopolimeri hidrogeli nanoceluloza velikost mreže matematično modeliranje true false true Angleški jezik Slovenski jezik Članek v reviji 2020-05-22 11:56:40 2020-05-22 11:59:43 2022-08-28 03:47:39 0000-00-00 00:00:00 2020 0 0 Str. 557-569 Vol. 159 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 678 0141-8130 10.1016/j.ijbiomac.2020.05.088 15760387 25637888 RAZ_Kopac_Tilen_2020.pdf RAZ_Kopac_Tilen_2020.pdf 1 B02EB30F45EA052032B650B3E943E59A d0edbdaa241fd4cccb86878419ab9bcc2b86d73440373edf8383ad99e799aae8 a574adc7-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=140610 https://www.sciencedirect.com/science/article/pii/S0141813020332414 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=129625 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0