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Lactational exposure to dioxin-like polychlorinated biphenyl 169 and nondioxin-like polychlorinated biphenyl 155 : effects on rat femur growth, biomechanics and mineral composition
Brankovič, Jana (Avtor), Fazarinc, Gregor (Avtor), Antanasova, Maja (Avtor), Jevnikar, Peter (Avtor), Jan, Janja (Avtor), Anders, Ines (Avtor), Pavšič Vrtač, Katarina (Avtor), Jakovac-Strajn, Breda (Avtor), Antolinc, David (Avtor), Vrecl, Milka (Avtor)

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URLURL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0147651319305159?via%3Dihub Povezava se odpre v novem oknu

Izvleček
Exposure to polychlorinated biphenyls (PCBs), which are persistent lipophilic environmental pollutants, has a variety of adverse effects on wildlife and human health, including bone mineralization, growth and mechanical strength. The present study evaluated the effects of lactational exposure to nondioxin-like PCB-155 and dioxin-like PCB-169, individually and in combination, on pubertal rat femur development and its biomechanics. After offspring delivery, Wistar rat mothers were divided into four groups, i.e., PCB-169, PCB-155, PCB-155+169 and control, and were administered PCBs intraperitoneally. Data on bone geometry, biomechanics and mineral composition were obtained by analysis of femurs from 42-day-old offspring by microCT scanning, three-point bending test and inductively coupled plasma mass spectrometry. Decreased somatic mass and femur size, i.e., mass, periosteal circumference and cross sectional area, were observed in the PCB-169 and PCB-155 groups. Additionally, lactational exposure to planar PCB-169 resulted in harder and more brittle bones containing higher amounts of minerals. Combined exposure to structurally and functionally different PCBs demonstrated only mild alterations in bone width and mineralization. To conclude, our results demonstrated that alterations, observed on postnatal day 42, were primarily induced by PCB-169, while toxicity from both of the individual congeners may have been reduced in the combined group.

Jezik:Angleški jezik
Ključne besede:polychlorinated biphenyls, bone, biochemical parameters, geometry, biomechanics, rats
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2019
Založnik:Academic Press
Št. strani:str. 106-113
Številčenje:Vol. 180
UDK:611
ISSN pri članku:0147-6513
DOI:10.1016/j.ecoenv.2019.04.076 Povezava se odpre v novem oknu
COBISS.SI-ID:4812666 Povezava se odpre v novem oknu
Avtorske pravice:založnik
Licenca:CC BY-NC-ND 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Število ogledov:164
Število prenosov:34
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Gradivo je del revije

Naslov:Ecotoxicology and environmental safety
Skrajšan naslov:Ecotoxicol. environ. saf.
Založnik:Academic Press.
ISSN:0147-6513
COBISS.SI-ID:25368320 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053, P3-0374
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih; Trajnostno kmetijstvo

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