Lactational exposure to dioxin-like polychlorinated biphenyl 169 and nondioxin-like polychlorinated biphenyl 155 : effects on rat femur growth, biomechanics and mineral composition

Brankovič, Jana (avtor), Fazarinc, Gregor (avtor), Antanasova, Maja (avtor), Jevnikar, Arne Peter (avtor), Jan, Janja (avtor), Anders, Ines (avtor), Pavšič Vrtač, Katarina (avtor), Jakovac-Strajn, Breda (avtor), Antolinc, David (avtor), Vrecl, Milka (avtor)

Exposure to polychlorinated biphenyls (PCBs), which are persistent lipophilic environmental pollutants, has a variety of adverse effects on wildlife and human health, including bone mineralization, growth and mechanical strength. The present study evaluated the effects of lactational exposure to nondioxin-like PCB-155 and dioxin-like PCB-169, individually and in combination, on pubertal rat femur development and its biomechanics. After offspring delivery, Wistar rat mothers were divided into four groups, i.e., PCB-169, PCB-155, PCB-155+169 and control, and were administered PCBs intraperitoneally. Data on bone geometry, biomechanics and mineral composition were obtained by analysis of femurs from 42-day-old offspring by microCT scanning, three-point bending test and inductively coupled plasma mass spectrometry. Decreased somatic mass and femur size, i.e., mass, periosteal circumference and cross sectional area, were observed in the PCB-169 and PCB-155 groups. Additionally, lactational exposure to planar PCB-169 resulted in harder and more brittle bones containing higher amounts of minerals. Combined exposure to structurally and functionally different PCBs demonstrated only mild alterations in bone width and mineralization. To conclude, our results demonstrated that alterations, observed on postnatal day 42, were primarily induced by PCB-169, while toxicity from both of the individual congeners may have been reduced in the combined group.

• Jezik: Angleški jezik
• Ključne besede: polychlorinated biphenyls, bone, biochemical parameters, geometry, biomechanics, rats
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Recenzirani rokopis
• Založnik: Academic Press
• Leto izida: 2019
• Št. strani: Str. 106-113
• Številčenje: Vol. 180
• PID: 20.500.12556/RUL-108896
• UDK: 611
• ISSN pri članku: 0147-6513
• DOI: 10.1016/j.ecoenv.2019.04.076
• COBISS.SI-ID: 4812666

Avtorske pravice

založnik

• Datum objave v RUL: 31.07.2019

Gradivo je del revije

• Naslov: Ecotoxicology and environmental safety
• Skrajšan naslov: Ecotoxicol. environ. saf.
• Založnik: Elsevier
• ISSN: 0147-6513
• COBISS.SI-ID: 25368320

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
• Začetek licenciranja: 31.07.2019

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0053, P3-0374
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih; Trajnostno kmetijstvo